Caenorhabditis elegans      PML nuclear body


※ PML nuclear body introduction

    PML nuclear bodies are matrix-associated domains that recruit an astonishing variety of seemingly unrelated proteins. Since their discovery in the early 1960s, PML bodies have fascinated cell biologists because of their beauty and their tight association with cellular disorders. The identification of PML, a gene involved in an oncogenic chromosomal translocation, as the key organizer of these domains drew instant interest onto them. The multiple levels of PML body regulation by a specific posttranslational modification, sumoylation, have raised several unsolved issues. Functionally, PML bodies may sequester, modify or degrade partner proteins, but in many ways, PML bodies still constitute an enigma (1).

Reference
1. Lallemand-Breitenbach, V. (2010) PML nuclear bodies. Cold Spring Harb Perspect Biol, 2(5):a000661. PMID: 20452955


There are 22 genes.  Reviewed (5 or Unreviewed (17

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Cae-2130
WBGene00008968
D3YT16
elli-1
2
LLPS-Cae-0028
WBGene00003951
Q9XUV0
pbs-5
3
LLPS-Cae-0196
WBGene00004454
P48166
rpl-36.A
4
LLPS-Cae-0056
WBGene00004888
P55853
smo-1
5
LLPS-Cae-0230
WBGene00006706
Q95017
ubc-9
6
LLPS-Cae-1043
WBGene00000226
Q22258
atl-1
7
LLPS-Cae-1932
WBGene00000264
B6VQ60
brc-1
8
LLPS-Cae-1913
WBGene00021502
O76726
CELE_Y40D12A.1
9
LLPS-Cae-1634
WBGene00001620
Q10901
glt-1
10
LLPS-Cae-1862
WBGene00001865
O18017
him-6
11
LLPS-Cae-0665
WBGene00019627
Q09589
hira-1
12
LLPS-Cae-1273
WBGene00002007
P27420
hsp-3
13
LLPS-Cae-0543
WBGene00002075
Q9BIB8
imb-1
14
LLPS-Cae-1351
WBGene00002196
P28548
kin-10
15
LLPS-Cae-1689
WBGene00015133
P34264
mrpl-11
16
LLPS-Cae-1867
WBGene00011614
G5EEG1
nfya-1
17
LLPS-Cae-1364
WBGene00022448
Q9N492
pinn-1
18
LLPS-Cae-1916
WBGene00006606
Q22036
tra-3
19
LLPS-Cae-1921
WBGene00006817
Q19326
unc-85
20
LLPS-Cae-1050
WBGene00012205
Q23126
W02B12.10
21
LLPS-Cae-0827
WBGene00006961
Q9U7E0
xnp-1
22
LLPS-Cae-1371
WBGene00002078
Q23089
xpo-1