※ Nuclear pore complex introduction

    The nuclear pore is proposed to be a LLPS stress granules initially condense to form stable cores, possibly with a nascent shell layer, and these cores merge into larger structures through interactions between the shell structures (1). A stable core assemblies could provide a structural platform for the formation of stress granules, due to the high concentration of IDRs on stress granule components to then rapidly phase-separate a dynamic shell that grows as a result of fusion with other small granules and surface exchange with an increasing pool of untranslating mRNPs. This general principle is also seen in the formation of the nuclear pore, wherein the creation of a high local concentration of FG repeat proteins by the structure of the nuclear pore, allows for a phase transition within the nuclear pore itself, even if the interactions between the FG repeats are relatively weak and non-specific (1).

Reference
1. Wheeler, J. R., Matheny, T., Jain, S., Abrisch, R., & Parker, R. (2016) Distinct stages in stress granule assembly and disassembly. Elife, 5. PMID: 27602576

  Reviewed (0)  or Unreviewed (3) 

No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Sei-1100	SETIT_034064mg	K4A5B0	101763385
2		LLPS-Sei-0472	SETIT_000473mg	A0A368RDR3	SETIT_5G387300v2
3		LLPS-Sei-1316	SETIT_009305mg	A0A368S2Q7	SETIT_7G335200v2