Xenopus tropicalis      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 38 genes.  Reviewed (0 or Unreviewed (38

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Xet-1224
ENSXETG00000019507.3
2
LLPS-Xet-0858
ENSXETG00000003985.3
F6UCE8
caprin1
3
LLPS-Xet-3378
ENSXETG00000012731.3
F7AUA0
cpeb4
4
LLPS-Xet-1926
ENSXETG00000017825.3
Q5XH91
ddx1
5
LLPS-Xet-0247
ENSXETG00000015477.3
F7CDY4
ddx3x
6
LLPS-Xet-0034
ENSXETG00000012580.2
Q6P4W2
ddx5
7
LLPS-Xet-1247
ENSXETG00000001182.3
A9UMS0
eef1a1
8
LLPS-Xet-0103
ENSXETG00000020093.3
F6XD74
eif2a
9
LLPS-Xet-0348
ENSXETG00000011221.3
Q6GL89
eif2s1
10
LLPS-Xet-0715
ENSXETG00000009316.3
F6ZT05
eif4e
11
LLPS-Xet-2343
ENSXETG00000008680.3
A4QNI8
elavl4
12
LLPS-Xet-2303
ENSXETG00000024796.2
Q6P3N0
ewsr1
13
LLPS-Xet-0909
ENSXETG00000019647.3
Q6GLC9
fmr1
14
LLPS-Xet-0083
ENSXETG00000019441.3
Q5BJ56
fxr1
15
LLPS-Xet-2055
ENSXETG00000010712.3
Q5BL67
g3bp1
16
LLPS-Xet-1624
ENSXETG00000003833.3
F6ZMQ9
hnrnpa0
17
LLPS-Xet-0489
ENSXETG00000021277.3
F6XNZ3
hnrnpa1
18
LLPS-Xet-1157
ENSXETG00000012170.3
F6TA26
hnrnpa2b1
19
LLPS-Xet-1073
ENSXETG00000003836.2
F6ZMQ0
hnrnpab
20
LLPS-Xet-1542
ENSXETG00000012569.3
Q537I0
hnrnpd
21
LLPS-Xet-1983
ENSXETG00000011386.3
F6RU04
hnrnpu
22
LLPS-Xet-0337
ENSXETG00000005246.3
F6VEI6
khdrbs1
23
LLPS-Xet-0741
ENSXETG00000009517.3
F6WH95
ncl
24
LLPS-Xet-2207
ENSXETG00000020868.2
F6UXS0
nono
25
LLPS-Xet-a056
ENSXETG00000000014.3
F6VWN2
psd
26
LLPS-Xet-3400
ENSXETG00000003837.1
A9UL75
pura
27
LLPS-Xet-3318
ENSXETG00000011290.3
F7A2L1
rbpms
28
LLPS-Xet-3769
ENSXETG00000000067.3
F7C1Y6
ripk4
29
LLPS-Xet-0449
ENSXETG00000006914.3
B0BM43
rpl3
30
LLPS-Xet-2936
ENSXETG00000011523.3
Q561P3
rtcb
31
LLPS-Xet-2261
ENSXETG00000012195.3
F7B7W9
rtraf
32
LLPS-Xet-3056
ENSXETG00000005385.3
F6ZHC7
srsf12
33
LLPS-Xet-0415
ENSXETG00000001783.3
F6XG62
stau1
34
LLPS-Xet-1722
ENSXETG00000011826.3
Q5M7M7
stau2
35
LLPS-Xet-1698
ENSXETG00000018075.3
B1WBI4
syncrip
36
LLPS-Xet-1998
ENSXETG00000001837.3
Q6DJS4
trim2
37
LLPS-Xet-0548
ENSXETG00000004691.3
F6TSI0
trim3
38
LLPS-Xet-1173
ENSXETG00000021272.3
F6XPK6
znf385a