Pelodiscus sinensis      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 39 genes.  Reviewed (0 or Unreviewed (39

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Pes-0239
ENSPSIG00000011217.1
K7FX51
2
LLPS-Pes-0782
ENSPSIG00000002361.1
K7F2Y4
3
LLPS-Pes-1924
ENSPSIG00000000035.1
K7EW75
4
LLPS-Pes-2103
ENSPSIG00000004417.1
K7F9K8
5
LLPS-Pes-3431
ENSPSIG00000004486.1
K7F9X1
6
LLPS-Pes-1656
ENSPSIG00000017541.1
K7GHL5
ALYREF
7
LLPS-Pes-0902
ENSPSIG00000007750.1
K7FL42
CAPRIN1
8
LLPS-Pes-2091
ENSPSIG00000012292.1
K7G071
DDX1
9
LLPS-Pes-0919
ENSPSIG00000010830.1
K7FVN5
DDX5
10
LLPS-Pes-2100
ENSPSIG00000005644.1
K7FDR6
EIF2A
11
LLPS-Pes-0008
ENSPSIG00000014235.1
K7G6R2
EIF2S1
12
LLPS-Pes-1720
ENSPSIG00000017812.1
K7GIL1
EIF2S2
13
LLPS-Pes-2102
ENSPSIG00000018060.1
K7GJE3
EIF4E
14
LLPS-Pes-3462
ENSPSIG00000008545.1
K7FN44
ELAVL4
15
LLPS-Pes-2226
ENSPSIG00000004329.1
K7F9B6
EWSR1
16
LLPS-Pes-1591
ENSPSIG00000009079.1
K7FPX0
FMR1
17
LLPS-Pes-a962
ENSPSIG00000008173.1
K7FLZ1
FXR2
18
LLPS-Pes-0445
ENSPSIG00000015000.1
K7G9G2
G3BP1
19
LLPS-Pes-0944
ENSPSIG00000002659.1
K7F3X0
HNRNPA2B1
20
LLPS-Pes-2887
ENSPSIG00000010617.1
K7FUP0
HNRNPAB
21
LLPS-Pes-0054
ENSPSIG00000017029.1
K7GFV4
HNRNPD
22
LLPS-Pes-2958
ENSPSIG00000005253.1
K7FCF6
HNRNPU
23
LLPS-Pes-0426
ENSPSIG00000005721.1
K7FDU5
KHDRBS1
24
LLPS-Pes-0269
ENSPSIG00000016027.1
K7GCT9
MAPK8
25
LLPS-Pes-0998
ENSPSIG00000010678.1
K7FV80
NONO
26
LLPS-Pes-a057
ENSPSIG00000014043.1
K7G610
PSD2
27
LLPS-Pes-1989
ENSPSIG00000005168.1
K7FC31
PSPC1
28
LLPS-Pes-0980
ENSPSIG00000007145.1
K7FIJ6
RBM3
29
LLPS-Pes-1958
ENSPSIG00000006136.1
K7FF84
RBPMS
30
LLPS-Pes-2744
ENSPSIG00000006258.1
K7FFK3
RIPK4
31
LLPS-Pes-0985
ENSPSIG00000011501.1
K7FXY0
RPL3
32
LLPS-Pes-1978
ENSPSIG00000011690.1
K7FY75
RTCB
33
LLPS-Pes-0081
ENSPSIG00000009863.1
K7FSC4
RTRAF
34
LLPS-Pes-0302
ENSPSIG00000011494.1
K7FXU7
SFPQ
35
LLPS-Pes-3513
ENSPSIG00000017849.1
K7GIM3
SRSF10
36
LLPS-Pes-1034
ENSPSIG00000010731.1
K7FV25
STAU1
37
LLPS-Pes-0100
ENSPSIG00000003686.1
K7F790
STAU2
38
LLPS-Pes-1541
ENSPSIG00000012306.1
K7G089
SYNCRIP
39
LLPS-Pes-0083
ENSPSIG00000015687.1
K7GBP3
TRIM2