Oryzias latipes      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 33 genes.  Reviewed (0 or Unreviewed (33

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Orl-2440
ENSORLG00000012331.2
H2MA86
ALYREF
2
LLPS-Orl-1358
ENSORLG00000004783.2
H2LJ36
caprin1
3
LLPS-Orl-2436
ENSORLG00000001711.2
A0A3B3HQZ2
CPEB4 (1 of many)
4
LLPS-Orl-0419
ENSORLG00000016709.2
H2MQ88
ddx1
5
LLPS-Orl-0787
ENSORLG00000013621.2
H2MES5
ddx3x
6
LLPS-Orl-0813
ENSORLG00000007614.2
Q9YIC0
eef1a
7
LLPS-Orl-1504
ENSORLG00000003548.2
H2LEP1
eif2s2
8
LLPS-Orl-1744
ENSORLG00000028487.1
H2MRQ1
elavl4
9
LLPS-Orl-2252
ENSORLG00000006712.2
H2LQT4
ewsr1
10
LLPS-Orl-3973
ENSORLG00000009094.2
H2LZ37
fmr1
11
LLPS-Orl-1019
ENSORLG00000011787.3
H2M8G1
fxr1
12
LLPS-Orl-0003
ENSORLG00000011422.2
H2M755
g3bp1
13
LLPS-Orl-2612
ENSORLG00000015098.2
H2MJS4
LOC101160075
14
LLPS-Orl-1878
ENSORLG00000004135.2
H2LGS3
LOC101164593
15
LLPS-Orl-0955
ENSORLG00000017636.2
H2MTG9
LOC101166761
16
LLPS-Orl-0514
ENSORLG00000001470.2
A0A3B3HJ12
LOC101166874
17
LLPS-Orl-2700
ENSORLG00000004232.3
H2LH46
LOC101167184
18
LLPS-Orl-3473
ENSORLG00000023176.1
A0A3B3I810
LOC101168026
19
LLPS-Orl-1432
ENSORLG00000006100.2
H2LNP0
LOC101168390
20
LLPS-Orl-3181
ENSORLG00000004188.2
A0A3B3HRZ8
LOC101169131
21
LLPS-Orl-2520
ENSORLG00000007485.2
A0A3B3HA79
LOC101170514
22
LLPS-Orl-0533
ENSORLG00000026044.1
A0A3B3I0V5
LOC101170948
23
LLPS-Orl-1994
ENSORLG00000001833.2
H2L8V3
LOC101171014
24
LLPS-Orl-0798
ENSORLG00000020884.2
A0A3B3HBQ9
LOC101174409
25
LLPS-Orl-2107
ENSORLG00000007055.4
H2LS06
ncl
26
LLPS-Orl-0775
ENSORLG00000012801.2
H2MBV1
nono
27
LLPS-Orl-3032
ENSORLG00000012500.2
H2MAU2
ripk4
28
LLPS-Orl-2945
ENSORLG00000020093.2
H2N0L9
rtcb
29
LLPS-Orl-3296
ENSORLG00000003840.2
H2LFQ4
rtraf
30
LLPS-Orl-1203
ENSORLG00000007459.2
H2LTD3
sfpq
31
LLPS-Orl-2543
ENSORLG00000007691.2
H2LU61
srsf10
32
LLPS-Orl-0961
ENSORLG00000014840.2
H2MIX4
syncrip
33
LLPS-Orl-2288
ENSORLG00000008416.2
H2LWS3
trim2