Macaca mulatta      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 42 genes.  Reviewed (0 or Unreviewed (42

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mam-0989
ENSMMUG00000037648.1
A0A1D5QBC4
2
LLPS-Mam-2768
ENSMMUG00000013388.3
A0A1D5RAY2
3
LLPS-Mam-0204
ENSMMUG00000012884.3
A0A1D5Q4N1
ALYREF
4
LLPS-Mam-2737
ENSMMUG00000021643.3
F7FA40
CAPRIN1
5
LLPS-Mam-3392
ENSMMUG00000022101.3
F7DU86
CIRBP
6
LLPS-Mam-1371
ENSMMUG00000019926.3
G7MU03
CPEB4
7
LLPS-Mam-0999
ENSMMUG00000023437.3
A0A1D5REB1
DDX1
8
LLPS-Mam-1049
ENSMMUG00000017569.3
A0A1D5Q9J1
DDX3X
9
LLPS-Mam-2901
ENSMMUG00000009463.3
F7A985
DDX5
10
LLPS-Mam-0650
ENSMMUG00000017696.3
F6WKS9
EIF2A
11
LLPS-Mam-1320
ENSMMUG00000021419.3
F7EFD7
EIF2S1
12
LLPS-Mam-2808
ENSMMUG00000018095.3
I0FW48
EIF2S2
13
LLPS-Mam-1484
ENSMMUG00000011066.3
A0A1D5QY25
EIF4E
14
LLPS-Mam-0003
ENSMMUG00000021933.3
F6T438
ELAVL4
15
LLPS-Mam-2464
ENSMMUG00000021374.3
F7FI06
EWSR1
16
LLPS-Mam-3109
ENSMMUG00000015814.3
I0FIR3
FMR1
17
LLPS-Mam-0140
ENSMMUG00000012105.3
F6W8C6
FXR1
18
LLPS-Mam-1067
ENSMMUG00000013510.3
F6ZDG6
FXR2
19
LLPS-Mam-2190
ENSMMUG00000014701.3
F7GTP0
G3BP1
20
LLPS-Mam-1428
ENSMMUG00000003619.3
I2CYL4
HNRNPA2B1
21
LLPS-Mam-0815
ENSMMUG00000021098.3
F7GWA9
HNRNPU
22
LLPS-Mam-2742
ENSMMUG00000023438.3
F7F4N3
KHDRBS1
23
LLPS-Mam-3244
ENSMMUG00000012989.3
F7HT55
LOC711588
24
LLPS-Mam-1700
ENSMMUG00000004060.3
F6ZKB3
MAPK8
25
LLPS-Mam-0263
ENSMMUG00000004934.3
A0A1D5R884
MND1
26
LLPS-Mam-0366
ENSMMUG00000018094.3
H9H3Z4
NCL
27
LLPS-Mam-0629
ENSMMUG00000020481.3
F6UC36
NONO
28
LLPS-Mam-a063
ENSMMUG00000002993.3
F6VVF5
PSD
29
LLPS-Mam-2603
ENSMMUG00000020262.3
F6XYS7
PSPC1
30
LLPS-Mam-2170
ENSMMUG00000010305.3
F6T2C6
PURA
31
LLPS-Mam-2229
ENSMMUG00000000458.3
F6YR70
RBPMS
32
LLPS-Mam-1774
ENSMMUG00000018043.3
F7EV70
RIPK4
33
LLPS-Mam-2758
ENSMMUG00000010029.3
F6R318
RPL3
34
LLPS-Mam-3643
ENSMMUG00000006720.3
F7HFI7
RTCB
35
LLPS-Mam-0383
ENSMMUG00000018200.3
F7E9I3
RTRAF
36
LLPS-Mam-0908
ENSMMUG00000019154.3
F6SSM0
SFPQ
37
LLPS-Mam-3326
ENSMMUG00000013784.3
H9H3N2
SRSF10
38
LLPS-Mam-3211
ENSMMUG00000002302.3
A0A1D5RAC9
STAU1
39
LLPS-Mam-2744
ENSMMUG00000021588.3
A0A1D5QGN8
STAU2
40
LLPS-Mam-0933
ENSMMUG00000012575.3
F7FEL4
SYNCRIP
41
LLPS-Mam-1992
ENSMMUG00000007728.3
A0A1D5RG25
TRIM3
42
LLPS-Mam-1131
ENSMMUG00000016669.3
F7H4S7
ZNF385A