Anolis carolinensis      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 41 genes.  Reviewed (0 or Unreviewed (41

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Anc-2161
ENSACAG00000013621.3
H9GK91
CAPRIN1
2
LLPS-Anc-3807
ENSACAG00000015039.3
G1KQM8
CPEB4
3
LLPS-Anc-1040
ENSACAG00000011036.3
G1KL19
DDX1
4
LLPS-Anc-2061
ENSACAG00000017928.3
G1KUJ3
ddx3x
5
LLPS-Anc-1522
ENSACAG00000000843.3
H9G4M7
ddx5
6
LLPS-Anc-1473
ENSACAG00000004556.3
H9G990
eef1a1
7
LLPS-Anc-2178
ENSACAG00000007685.3
G1KGY6
EIF2A
8
LLPS-Anc-1058
ENSACAG00000005994.3
H9GAU9
EIF2S1
9
LLPS-Anc-0005
ENSACAG00000009041.3
G1KIG2
EIF2S2
10
LLPS-Anc-0356
ENSACAG00000014186.3
H9GKT5
EIF4E
11
LLPS-Anc-0427
ENSACAG00000004527.3
G1KCV7
ELAVL4
12
LLPS-Anc-2346
ENSACAG00000009298.2
H9GF55
EWSR1
13
LLPS-Anc-0528
ENSACAG00000007899.2
H9GDA8
FMR1
14
LLPS-Anc-0831
ENSACAG00000003918.3
G1KCG1
FXR1
15
LLPS-Anc-2217
ENSACAG00000009792.3
H9GFQ4
G3BP1
16
LLPS-Anc-0440
ENSACAG00000007169.3
G1KG94
hnrnpa1
17
LLPS-Anc-1041
ENSACAG00000012992.3
G1KN60
HNRNPA2B1
18
LLPS-Anc-1777
ENSACAG00000016946.3
G1KTC4
HNRNPAB
19
LLPS-Anc-3613
ENSACAG00000010342.3
G1KK21
HNRNPD
20
LLPS-Anc-0392
ENSACAG00000004511.2
H9G948
HNRNPU
21
LLPS-Anc-0012
ENSACAG00000011693.3
H9GI32
KHDRBS1
22
LLPS-Anc-0522
ENSACAG00000023931.1
H9GVK5
LOC100554570
23
LLPS-Anc-2666
ENSACAG00000013718.3
H9GK64
LOC100554762
24
LLPS-Anc-1487
ENSACAG00000011361.2
H9GHV5
MAPK8
25
LLPS-Anc-1925
ENSACAG00000001006.3
H9G4M1
ncl
26
LLPS-Anc-1590
ENSACAG00000015026.1
H9GLW7
NONO
27
LLPS-Anc-a059
ENSACAG00000014133.3
H9GKQ9
PSD
28
LLPS-Anc-1348
ENSACAG00000002093.2
G1KAB1
PSPC1
29
LLPS-Anc-2224
ENSACAG00000003012.3
H9G702
RBPMS
30
LLPS-Anc-2276
ENSACAG00000005401.3
G1KE26
RIPK4
31
LLPS-Anc-2259
ENSACAG00000007688.3
G1KH03
RPL3
32
LLPS-Anc-3224
ENSACAG00000014817.3
G1KQE8
RTCB
33
LLPS-Anc-3552
ENSACAG00000017886.3
H9GPU9
RTRAF
34
LLPS-Anc-2629
ENSACAG00000013307.2
H9GJV2
sfpq
35
LLPS-Anc-3553
ENSACAG00000005327.2
H9GA31
SRSF10
36
LLPS-Anc-2169
ENSACAG00000015909.3
G1KRV7
STAU1
37
LLPS-Anc-0028
ENSACAG00000012977.3
G1KN39
STAU2
38
LLPS-Anc-1865
ENSACAG00000015234.2
G1KQW6
SYNCRIP
39
LLPS-Anc-2396
ENSACAG00000015934.3
G1KRX0
TRIM2
40
LLPS-Anc-1053
ENSACAG00000015325.2
H9GM75
TRIM3
41
LLPS-Anc-2642
ENSACAG00000007594.3
G1KGU8
ZNF385A