Schizosaccharomyces pombe      Mitochondrial RNA granule


※ Mitochondrial RNA granule introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Mitochondrial RNA granules is a kind of these bodies of spherical shape that located in mitochondria with mitochondrial mRNAs and mitochondrial ribosomes components and it’s proved to be related to the posttranscriptional RNA processing and biogenesis of mitochondrial ribosomes (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 10 genes.  Reviewed (1 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Scp-0041
SPCC736.06
O94242
msd1
2
LLPS-Scp-0792
SPBC1347.13c
O94631
mrm1
3
LLPS-Scp-1257
SPBC2G2.15c
P78860
mrm2
4
LLPS-Scp-1513
SPCC4G3.06c
P87232
mrpl4
5
LLPS-Scp-1438
SPBC19C2.12
Q9UUC8
mrpl51
6
LLPS-Scp-1553
SPAC29A4.03c
O14006
mrps9
7
LLPS-Scp-0563
SPAC26H5.12
O13993
rpo41
8
LLPS-Scp-0655
SPAC16E8.10c
O13744
rsm7
9
LLPS-Scp-0441
SPCC965.04c
O59824
SPCC965.04c
10
LLPS-Scp-1025
SPAC637.11
O94445
suv3