Monodelphis domestica      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 17 genes.  Reviewed (0 or Unreviewed (17

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mod-2480
ENSMODG00000020654.4
F7E5Y1
2
LLPS-Mod-3469
ENSMODG00000007271.2
F7FQR2
3
LLPS-Mod-0638
ENSMODG00000002637.5
F7FU94
BAHCC1
4
LLPS-Mod-0804
ENSMODG00000018180.3
F7BU08
CASP8AP2
5
LLPS-Mod-1962
ENSMODG00000010755.3
F7FWI0
CPSF1
6
LLPS-Mod-1475
ENSMODG00000002042.3
F6QCB9
CPSF2
7
LLPS-Mod-3427
ENSMODG00000014703.3
F7D3K9
CPSF3
8
LLPS-Mod-2151
ENSMODG00000001367.3
F7FVV8
CPSF4
9
LLPS-Mod-1025
ENSMODG00000005757.2
F6QDS6
CTCF
10
LLPS-Mod-2061
ENSMODG00000008303.4
F7CW27
CTR9
11
LLPS-Mod-0607
ENSMODG00000001311.3
F7BEL2
DDX20
12
LLPS-Mod-3898
ENSMODG00000017006.3
F6QF38
GON4L
13
LLPS-Mod-2825
ENSMODG00000013267.2
F7D9I7
HINFP
14
LLPS-Mod-0832
ENSMODG00000016081.3
F7G9F5
LOC100030264
15
LLPS-Mod-0871
ENSMODG00000023328.1
F6V8Y0
LSM10
16
LLPS-Mod-3352
ENSMODG00000008314.4
F7FGU7
LSM11
17
LLPS-Mod-0561
ENSMODG00000014648.3
F7EQA1
NPAT