Loxodonta africana      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 16 genes.  Reviewed (0 or Unreviewed (16

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Loa-0774
ENSLAFG00000007483.3
G3T035
2
LLPS-Loa-2684
ENSLAFG00000005800.4
G3SWX5
3
LLPS-Loa-2986
ENSLAFG00000012427.3
G3T9D2
CASP8AP2
4
LLPS-Loa-2781
ENSLAFG00000022601.2
G3TN49
CPSF1
5
LLPS-Loa-3533
ENSLAFG00000004891.2
G3SV49
CPSF2
6
LLPS-Loa-0107
ENSLAFG00000009467.3
G3T3S7
CPSF3
7
LLPS-Loa-1222
ENSLAFG00000000159.3
G3SL71
CPSF4
8
LLPS-Loa-2074
ENSLAFG00000007101.3
G5E6X2
CTCF
9
LLPS-Loa-3337
ENSLAFG00000012801.4
G3TA45
CTR9
10
LLPS-Loa-1430
ENSLAFG00000002605.3
G3SQT5
FIP1L1
11
LLPS-Loa-1041
ENSLAFG00000006180.3
G3SXP1
H2AFV
12
LLPS-Loa-1523
ENSLAFG00000017500.2
G3TWB7
HINFP
13
LLPS-Loa-3281
ENSLAFG00000009600.2
G3T416
LSM10
14
LLPS-Loa-2109
ENSLAFG00000004928.2
G3SV74
LSM11
15
LLPS-Loa-0508
ENSLAFG00000013398.3
G3TB85
NPAT
16
LLPS-Loa-1398
ENSLAFG00000008726.3
G3T2E4
SYMPK