Komagataella pastoris      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Kop-1266
PAS_chr1-1_0015
C4QVU5
PAS_chr1-1_0015
2
LLPS-Kop-0290
PAS_chr1-1_0249
C4QWJ6
PAS_chr1-1_0249
3
LLPS-Kop-0215
PAS_chr1-3_0183
C4QVH3
PAS_chr1-3_0183
4
LLPS-Kop-1402
PAS_chr2-1_0816
C4QZW3
PAS_chr2-1_0816
5
LLPS-Kop-0145
PAS_chr3_0333
C4R485
PAS_chr3_0333
6
LLPS-Kop-0886
PAS_chr3_1035
C4R6B2
PAS_chr3_1035
7
LLPS-Kop-0570
PAS_chr4_0157
C4R707
PAS_chr4_0157