Carlito syrichta      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 15 genes.  Reviewed (0 or Unreviewed (15

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Cas-1083
ENSTSYG00000002808.2
2
LLPS-Cas-3252
ENSTSYG00000006673.2
3
LLPS-Cas-3847
ENSTSYG00000036115.1
4
LLPS-Cas-1759
ENSTSYG00000028560.1
A0A1U7UDI0
CPSF1
5
LLPS-Cas-0210
ENSTSYG00000009036.2
A0A1U7ULS8
CPSF2
6
LLPS-Cas-2379
ENSTSYG00000002967.2
A0A1U7UU30
CPSF3
7
LLPS-Cas-0004
ENSTSYG00000005712.2
A0A1U7T5J5
CPSF4
8
LLPS-Cas-1031
ENSTSYG00000007670.2
A0A1U7UDK0
CTCF
9
LLPS-Cas-1588
ENSTSYG00000006144.2
A0A1U7UBK0
CTR9
10
LLPS-Cas-2009
ENSTSYG00000000153.2
A0A1U7TAZ5
DDX20
11
LLPS-Cas-0928
ENSTSYG00000012226.2
A0A1U7U8P4
HINFP
12
LLPS-Cas-2208
ENSTSYG00000009647.2
A0A1U7TKI3
LOC103257607
13
LLPS-Cas-0677
ENSTSYG00000034555.1
A0A1U7TYH7
LOC103269282
14
LLPS-Cas-0817
ENSTSYG00000006268.2
A0A1U7SG51
SYMPK
15
LLPS-Cas-1063
ENSTSYG00000034279.1
A0A1U7U5H4
TP53