Pan paniscus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Pap-0553
ENSPPAG00000031680.1
A0A2R9AJH5
DDX20
2
LLPS-Pap-0063
ENSPPAG00000029090.1
A0A2R9A818
FUS
3
LLPS-Pap-2139
ENSPPAG00000043467.1
A0A2R9CRR1
GEMIN2
4
LLPS-Pap-1199
ENSPPAG00000030072.1
A0A2R9AAA4
GEMIN4
5
LLPS-Pap-0146
ENSPPAG00000043133.1
A0A2R9CGJ8
GEMIN5
6
LLPS-Pap-3160
ENSPPAG00000036509.1
A0A2R9BJ78
GEMIN6
7
LLPS-Pap-2839
ENSPPAG00000023831.1
A0A2R8ZLQ4
GEMIN7
8
LLPS-Pap-1712
ENSPPAG00000005337.1
A0A2R8Z8I5
GEMIN8
9
LLPS-Pap-1403
ENSPPAG00000035067.1
A0A2R9B2Q8
SNRNP70
10
LLPS-Pap-0682
ENSPPAG00000036674.1
A0A2R9BC65
STRAP
11
LLPS-Pap-0244
ENSPPAG00000039086.1
A0A2R9C1F8
TARDBP