Ornithorhynchus anatinus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Ora-0121
ENSOANG00000014013.2
F6SYB1
2
LLPS-Ora-1126
ENSOANG00000003318.2
F7AEF2
DDX20
3
LLPS-Ora-3078
ENSOANG00000005606.4
F7BAJ3
FUS
4
LLPS-Ora-0151
ENSOANG00000009929.2
F6SRX5
GEMIN4
5
LLPS-Ora-1799
ENSOANG00000005092.1
F7C7A3
GEMIN5
6
LLPS-Ora-0588
ENSOANG00000003420.1
F7DHY4
GEMIN6
7
LLPS-Ora-2197
ENSOANG00000008945.1
F7GDX8
GEMIN7
8
LLPS-Ora-3319
ENSOANG00000002604.2
F7E8F6
GEMIN8
9
LLPS-Ora-0303
ENSOANG00000001626.3
F7EJU6
LOC100081724
10
LLPS-Ora-0180
ENSOANG00000005213.2
F7BFR6
SNRNP70
11
LLPS-Ora-1814
ENSOANG00000013320.2
F7EDX1
TARDBP