Oreochromis niloticus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Orn-0586
ENSONIG00000007822.1
I3JLW0
2
LLPS-Orn-0880
ENSONIG00000016099.1
I3KGN5
3
LLPS-Orn-2581
ENSONIG00000002332.1
I3J227
4
LLPS-Orn-2610
ENSONIG00000012758.1
I3K4L5
5
LLPS-Orn-3019
ENSONIG00000012436.1
I3K3H0
6
LLPS-Orn-3213
ENSONIG00000020468.1
I3KXC7
7
LLPS-Orn-3364
ENSONIG00000019837.1
I3KV24
8
LLPS-Orn-3156
ENSONIG00000019495.1
I3KTU5
gemin2
9
LLPS-Orn-0116
ENSONIG00000016441.1
I3KHW1
gemin5
10
LLPS-Orn-2171
ENSONIG00000001003.1
I3IXD1
gemin8
11
LLPS-Orn-0518
ENSONIG00000011799.1
I3K158
LOC100698882