Mandrillus leucophaeus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mal-0498
ENSMLEG00000005722.1
A0A2K5XDS3
DDX20
2
LLPS-Mal-0523
ENSMLEG00000038040.1
A0A2K5ZIM2
FUS
3
LLPS-Mal-3386
ENSMLEG00000035575.1
A0A2K5Z4K9
GEMIN2
4
LLPS-Mal-0147
ENSMLEG00000039332.1
A0A2K5ZR17
GEMIN4
5
LLPS-Mal-2842
ENSMLEG00000032915.1
A0A2K5YPN0
GEMIN5
6
LLPS-Mal-2487
ENSMLEG00000038376.1
A0A2K5ZKM1
GEMIN6
7
LLPS-Mal-0812
ENSMLEG00000028032.1
A0A2K5XWV9
GEMIN7
8
LLPS-Mal-3968
ENSMLEG00000027629.1
A0A2K5XVE0
GEMIN8
9
LLPS-Mal-2074
ENSMLEG00000030967.1
A0A2K5YDK4
SNRNP70
10
LLPS-Mal-3090
ENSMLEG00000042689.1
A0A2K6AAW9
STRAP
11
LLPS-Mal-1698
ENSMLEG00000041791.1
A0A2K6A5S4
TARDBP