Lepisosteus oculatus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Leo-0559
ENSLOCG00000015777.1
W5NFL4
2
LLPS-Leo-0910
ENSLOCG00000015352.1
W5NE33
3
LLPS-Leo-0988
ENSLOCG00000017726.1
W5NMH1
4
LLPS-Leo-2077
ENSLOCG00000006604.1
W5MHW9
5
LLPS-Leo-2301
ENSLOCG00000010372.1
W5MWF7
6
LLPS-Leo-2687
ENSLOCG00000006840.1
W5MIR1
7
LLPS-Leo-2903
ENSLOCG00000011339.1
W5MZX4
8
LLPS-Leo-3141
ENSLOCG00000009221.1
W5MS93
9
LLPS-Leo-3759
ENSLOCG00000010057.1
W5MV91