Ficedula albicollis      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Fia-0221
ENSFALG00000012320.1
U3KCW5
2
LLPS-Fia-0194
ENSFALG00000000666.1
U3JD35
DDX20
3
LLPS-Fia-1943
ENSFALG00000006169.1
U3JUI4
GEMIN2
4
LLPS-Fia-0335
ENSFALG00000005780.1
U3JTC1
GEMIN4
5
LLPS-Fia-0101
ENSFALG00000008360.1
U3K106
GEMIN5
6
LLPS-Fia-1033
ENSFALG00000002361.1
U3JI51
GEMIN6
7
LLPS-Fia-0676
ENSFALG00000004451.1
U3JPC7
GEMIN8
8
LLPS-Fia-1162
ENSFALG00000009695.1
U3K510
STRAP
9
LLPS-Fia-0498
ENSFALG00000007199.1
U3JXL3
TARDBP