Ciona intestinalis      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 8 genes.  Reviewed (0 or Unreviewed (8

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Cii-0180
ENSCING00000014454.2
F6YAV6
2
LLPS-Cii-0483
ENSCING00000020168.1
H2Y1J7
3
LLPS-Cii-1369
ENSCING00000005927.3
F6ZHD7
4
LLPS-Cii-0432
ENSCING00000000050.3
Q4H2Q6
Ci-Tardbp
5
LLPS-Cii-0786
ENSCING00000000502.3
F6VQ02
LOC100176230
6
LLPS-Cii-0512
ENSCING00000006015.3
F6ZGG6
LOC100178141
7
LLPS-Cii-0750
ENSCING00000018224.1
H2XK66
LOC100179671
8
LLPS-Cii-2114
ENSCING00000012240.2
F7B5G8
LOC100181701