Carlito syrichta      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Cas-2009
ENSTSYG00000000153.2
A0A1U7TAZ5
DDX20
2
LLPS-Cas-2351
ENSTSYG00000011757.2
A0A1U7TUZ2
FUS
3
LLPS-Cas-0830
ENSTSYG00000003528.2
A0A1U7U8W8
GEMIN2
4
LLPS-Cas-0317
ENSTSYG00000010568.2
A0A1U7UL80
GEMIN5
5
LLPS-Cas-2736
ENSTSYG00000026011.1
A0A1U7U251
GEMIN6
6
LLPS-Cas-3760
ENSTSYG00000028251.1
A0A1U7SZ98
GEMIN8
7
LLPS-Cas-2900
ENSTSYG00000032350.1
A0A1U7SES4
LOC103249566
8
LLPS-Cas-0024
ENSTSYG00000012058.2
A0A1U7UJP8
LOC103270354
9
LLPS-Cas-1058
ENSTSYG00000006578.2
A0A1U7UK90
STRAP
10
LLPS-Cas-3433
ENSTSYG00000004077.2
A0A1U7SU45
TARDBP