Callithrix jacchus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Caj-0516
ENSCJAG00000023001.2
A0A2R8MT79
2
LLPS-Caj-0391
ENSCJAG00000013428.3
F6S3C8
DDX20
3
LLPS-Caj-2825
ENSCJAG00000003169.3
F7HVN9
FUS
4
LLPS-Caj-2791
ENSCJAG00000016248.3
F7I4W3
GEMIN2
5
LLPS-Caj-2248
ENSCJAG00000038327.1
U3E0L0
GEMIN4
6
LLPS-Caj-0162
ENSCJAG00000007336.2
F6VDQ0
GEMIN5
7
LLPS-Caj-1568
ENSCJAG00000015169.3
F7H9C8
GEMIN6
8
LLPS-Caj-1444
ENSCJAG00000022315.2
F7HUZ3
LOC100391187
9
LLPS-Caj-2098
ENSCJAG00000000193.3
F7D867
SNRNP70
10
LLPS-Caj-1303
ENSCJAG00000021593.3
F7INV0
STRAP
11
LLPS-Caj-0265
ENSCJAG00000002381.3
F7CL81
TARDBP