Sarcophilus harrisii      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Sah-0299
ENSSHAG00000015613.1
G3WSJ0
2
LLPS-Sah-0051
ENSSHAG00000010836.1
G3WB56
ATM
3
LLPS-Sah-2705
ENSSHAG00000003606.1
G3VLN5
ATMIN
4
LLPS-Sah-3015
ENSSHAG00000015877.1
G3WTE5
ATR
5
LLPS-Sah-1282
ENSSHAG00000011874.1
G3WEM9
FUS
6
LLPS-Sah-2184
ENSSHAG00000010034.1
G3W8C9
H2AFX
7
LLPS-Sah-1380
ENSSHAG00000014031.1
G3WM36
PRKDC
8
LLPS-Sah-1744
ENSSHAG00000010792.1
G3WB07
RAD50
9
LLPS-Sah-0694
ENSSHAG00000005667.1
G3VTK7
RBM45
10
LLPS-Sah-2548
ENSSHAG00000013019.1
G3WIL4
TP53BP1