Ictalurus punctatus      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Icp-2814
ENSIPUG00000008217.1
W6A318
ATM
2
LLPS-Icp-2504
ENSIPUG00000006337.1
A0A2D0QRY5
atmin
3
LLPS-Icp-0999
ENSIPUG00000015422.1
A0A2D0T6X7
atr
4
LLPS-Icp-2518
ENSIPUG00000008888.1
A0A2D0QBA5
LOC108260105
5
LLPS-Icp-1650
ENSIPUG00000005438.1
A0A2D0RD16
prkdc
6
LLPS-Icp-3841
ENSIPUG00000012572.1
A0A2D0T0Y9
rad50
7
LLPS-Icp-0931
ENSIPUG00000015843.1
A0A2D0PJI9
rad51
8
LLPS-Icp-3782
ENSIPUG00000019576.1
W5UE65
RBM45
9
LLPS-Icp-1312
ENSIPUG00000022895.1
A0A2D0Q9W3
tp53bp1