Carlito syrichta      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Cas-0351
ENSTSYG00000009678.2
A0A1U7TAS0
ATM
2
LLPS-Cas-3570
ENSTSYG00000036649.1
A0A1U7TZB2
ATMIN
3
LLPS-Cas-2433
ENSTSYG00000002718.2
A0A1U7UJL2
ATR
4
LLPS-Cas-2351
ENSTSYG00000011757.2
A0A1U7TUZ2
FUS
5
LLPS-Cas-0619
ENSTSYG00000026881.1
A0A1U7UKR6
LOC103270715
6
LLPS-Cas-0322
ENSTSYG00000026044.1
A0A1U7ULC3
LOC103275368
7
LLPS-Cas-2861
ENSTSYG00000004199.2
A0A1U7T1G9
PRKDC
8
LLPS-Cas-0187
ENSTSYG00000007636.2
A0A1U7TN14
RAD50
9
LLPS-Cas-0856
ENSTSYG00000000912.2
A0A1U7UL65
RAD51
10
LLPS-Cas-3919
ENSTSYG00000007757.2
A0A1U7TAY5
RBM45
11
LLPS-Cas-0590
ENSTSYG00000004830.2
A0A1U7TVW0
TP53BP1