Mus musculus      Cleavage body


※ Cleavage body introduction

    Cleavage bodies is a kind of nuclear PMLO (proteinaceous membrane-less organelles) located in Nucleus, It contains no DNA or RNA and it is fluid shaped as a spherical, it is associated with RNA metabolism, potentially serves as storage/assembly sites for proteins involved in transcription, splicing 3’-end processing of pre-mRNAs, and RNA degradation (1). They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 3 genes.  Reviewed (1 or Unreviewed (2

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mum-2171
ENSMUSG00000037149.10
Q91VR5
Ddx1
2
LLPS-Mum-0547
ENSMUSG00000041781.9
O35218
Cpsf2
3
LLPS-Mum-0009
ENSMUSG00000031256.11
Q8BIQ5
Cstf2