Canis familiaris Centrosome/Spindle pole body
※ Centrosome/Spindle pole body introduction A centrosome is a composite material comprising a pair of 200-nm-long barrel-shaped centrioles surrounded by a dynamic protein mass called the pericentriolar material (PCM), which organizes hundreds to thousands of microtubules that build and position the mitotic spindle in metazoans (1). The seemingly unstructured mitotic PCM provides most of the mass and microtubule nucleation capacity of the centrosome, Mitotic PCM could also be liquid like, the mitotic PCM first assembles through phase separation of SPD-5 molecules around the centrioles. Liquid–liquid phase separation of the SPD-5 scaffold followed by maturation into a gel could explain why mitotic PCM is both spherical and stable (1). Reference
1. Woodruff, J. B., Hyman, A. A., & Boke, E. (2018) Organization and Function of Non-dynamic Biomolecular Condensates. Trends Biochem Sci, 43(2), 81-94. PMID: 29258725
There are 604 genes. Reviewed (0)
or Unreviewed (604) 
※ Centrosome/Spindle pole body introduction A centrosome is a composite material comprising a pair of 200-nm-long barrel-shaped centrioles surrounded by a dynamic protein mass called the pericentriolar material (PCM), which organizes hundreds to thousands of microtubules that build and position the mitotic spindle in metazoans (1). The seemingly unstructured mitotic PCM provides most of the mass and microtubule nucleation capacity of the centrosome, Mitotic PCM could also be liquid like, the mitotic PCM first assembles through phase separation of SPD-5 molecules around the centrioles. Liquid–liquid phase separation of the SPD-5 scaffold followed by maturation into a gel could explain why mitotic PCM is both spherical and stable (1). Reference
1. Woodruff, J. B., Hyman, A. A., & Boke, E. (2018) Organization and Function of Non-dynamic Biomolecular Condensates. Trends Biochem Sci, 43(2), 81-94. PMID: 29258725
There are 604 genes. Reviewed (0)
or Unreviewed (604)