Ustilago maydis      Cajal body


※ Cajal body introduction

    Cajal bodies is a kind of non-membrane-bound nuclear bodies, formation of such sub-organelles usually involves dynamic processes, which can move within the nucleoplasm except when transiently immobilized through interaction with chromatin (1). The Cajal body has been suggested to be associated with telomere maintenance and maturation of the splicing machinery and processing of histone mRNA (2;3), it is rich in ribonucleoprotein (RNP) complexes and characterized by the marker protein coilin that interacts with many factors and thereby serves as a platform for the assembly of Cajal bodies (1). WRAP53β has been demonstrated to be an essential Cajal Body Component, it guides SMN across the cell to Cajal Bodies, and phosphorylation of WRAP53β by ATM promotes its involvement in the DNA damage response (4). besides, Fam118 is a newly identified component of Cajal bodies that is required for Cajal body formation (5). Defects in Cajal body formation are linked to impaired cell proliferation and splicing (6). In fact, Cajal bodies are not essential in telomerase function and telomere elongation ,whereas certain Cajal body factors such as WRAP53β clearly play important roles in telomere homeostasis (1).

References
1. Henriksson, S., & Farnebo, M. (2015) On the road with WRAP53beta: guardian of Cajal bodies and genome integrity. Front Genet, 6, 91. PMID: 25852739
2. Machyna, M., Heyn, P., & Neugebauer, K. M. (2013) Cajal bodies: where form meets function. Wiley Interdiscip Rev RNA, 4(1), 17-34. PMID: 23042601
3. Hutten, S., Chachami, G., Winter, U., Melchior, F., & Lamond, A. I. (2014) A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II. J. Cell. Sci., 127(Pt 5), 1065-1078. PMID: 24413172
4. Coucoravas, C., Dhanjal, S., Henriksson, S., Bohm, S., & Farnebo, M. (2017) Phosphorylation of the Cajal body protein WRAP53beta by ATM promotes its involvement in the DNA damage response. RNA Biol., 14(6), 804-813. PMID: 27715493
5. Li, Y., Fong, K. W., Tang, M., Han, X., Gong, Z., Ma, W, Chen, J. (2014) Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. J. Cell Sci., 127(Pt 9), 2029-2039. PMID:24569877
6. Lemm, I., Girard, C., Kuhn, A. N., Watkins, N. J., Schneider, M., Bordonne, R., & Luhrmann, R. (2006) Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies. Mol. Biol. Cell, 17(7), 3221-3231. PMID:16687569


There are 15 genes.  Reviewed (0 or Unreviewed (15

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Usm-0869
UMAG_04654
Q4P5F9
LEA1
2
LLPS-Usm-0074
UMAG_02561
Q4PBF2
NOP58
3
LLPS-Usm-0034
UMAG_06201
Q4P112
RVB1
4
LLPS-Usm-0507
UMAG_04226
Q4P6N7
RVB2
5
LLPS-Usm-0007
UMAG_02628
A0A0D1E492
UMAG_02628
6
LLPS-Usm-0065
UMAG_02859
A0A0D1C5C8
UMAG_02859
7
LLPS-Usm-0896
UMAG_06233
A0A0D1BUR5
UMAG_06233
8
LLPS-Usm-0337
UMAG_10312
A0A0D1DZ88
UMAG_10312
9
LLPS-Usm-0466
UMAG_10381
A0A0D1DWN1
UMAG_10381
10
LLPS-Usm-0893
UMAG_10698
A0A0D1BXY2
UMAG_10698
11
LLPS-Usm-0207
UMAG_10805
A0A0D1E7H0
UMAG_10805
12
LLPS-Usm-0687
UMAG_11178
A0A0D1DRT2
UMAG_11178
13
LLPS-Usm-0497
UMAG_11198
A0A0D1EAT9
UMAG_11198
14
LLPS-Usm-0412
UMAG_11734
A0A0D1C3D3
UMAG_11734
15
LLPS-Usm-0904
UMAG_11746
A0A0D1DUJ4
UMAG_11746